The folks at Carnegie Mellon University created an application called MailHide that will assist you in masquerading your e-mail address from spammers.
What it does is it only shows your e-mail address partially, like your…@domain.com. And if someone wants/needs to obtain your complete, true e-mail address, they can by solving two CAPTCHAs ((Completely Automated Public Turing test to tell Computers and Humans Apart)displayed…you know those forms that ask you to type in certain words.
They also provide an API. Cool! OK, hope this helps you decrease the spam you receive exponentially.